The number of ordered pairs $(u, v)$ in $S \times S$ with $u \neq v$ and $u \sim_H v$. This is twice the number of edges in the induced subgraph $H[S]$.
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The maximum edge-to-vertex ratio over nonempty subsets of $V(H)$, i.e. $m(H) = \max_{S \ne \emptyset} |E(H[S])| / |S|$.
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The probability that $G(n, p)$ contains $H$ as a (not necessarily induced) subgraph, computed by summing Bernoulli edge weights over all graphs $G$ on $n$ vertices that admit an injective graph homomorphism from $H$.
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The indicator of "there exists an injective homomorphism $H \hookrightarrow G$" is bounded by the sum of indicators over all injections, since at least one injection works whenever the existential holds.
The Bernoulli probability that $G$ contains the image of $H$ under a fixed injection $f : V(H) \hookrightarrow [n]$ is at most $p^{|E(H)|}$, since all $|E(H)|$ edges of $H$ must appear independently.
A densest-subgraph first-moment bound: there exists $k > 0$ depending on $H$ such that the probability of containing $H$ is bounded by $|p / n^{-1/m(H)}|^k$, the key nonnegativity-plus-upper-bound estimate underlying the first moment direction.
First moment side of Bollobás's threshold theorem. If $p_n / n^{-1/m(H)} \to 0$, then the probability that $G(n, p_n)$ contains $H$ as a subgraph tends to $0$.
Second moment side of Bollobás's threshold theorem. If $p_n / n^{-1/m(H)} \to \infty$, then the probability that $G(n, p_n)$ contains $H$ as a subgraph tends to $1$.
Bollobás's threshold theorem (Theorem 4.2.10, 1981). For every graph $H$ with positive maximum edge density $m(H)$, the function $n^{-1/m(H)}$ is a threshold for the property that $G(n, p)$ contains $H$.