Shorthand for the variance $\mathrm{Var}(X) = \mathbb{E}[(X - \mathbb{E}X)^2]$ of a random variable $X$ with respect to a measure $\mu$.
Instances For
Chebyshev's inequality. For an $L^2$ random variable $X$ and any $t > 0$, $$\mathbb{P}\bigl(|X - \mathbb{E}X| \ge t\bigr) \le \frac{\mathrm{Var}(X)}{t^2}.$$
Second moment bound on the probability of vanishing. If $X \in L^2$ and $\mathbb{E}X > 0$, then $\mathbb{P}(X = 0) \le \mathrm{Var}(X) / (\mathbb{E}X)^2$. This is Lemma 4.2.4 (Corollary 4.1.7) in Probabilistic Methods in Combinatorics.
Asymptotic second moment method (single measure). If a sequence $(X_n)$ of $L^2$ random variables on a common probability space has $\mathbb{E}X_n > 0$ and $\mathrm{Var}(X_n) / (\mathbb{E}X_n)^2 \to 0$, then $\mathbb{P}(X_n = 0) \to 0$.
Second moment method (Corollary 4.1.8). Given a sequence of probability spaces $(\Omega_n, \mu_n)$ and $L^2$ random variables $X_n$ with $\mathbb{E}_{\mu_n}[X_n] > 0$, if $\mathrm{Var}(X_n) / (\mathbb{E}X_n)^2 \to 0$ then $\mu_n(X_n = 0) \to 0$.